Original Kubios Publications and White Papers
The following publications describe certain functionalities of Kubios HRV software products or provide validation results for our HRV pre-processing and analysis algorithms. If you are using Kubios HRV software products in scientific research, we hope that you will cite these publications appropriately when you publish your research findings.
| Publication | Publication type & year | Relevance/Context |
|---|---|---|
| Hyrylä VV, Eronen T, Kupari S, Venojärvi M, Tikkanen HO, Tarvainen MP. Attenuated fast heart rate recovery suggests delayed parasympathetic reactivation after cessation of exercise in uncomplicated type 1 diabetes patients. Scientific Reports, 15 (Article 24136), Jul 2025, doi: https://doi.org/10.1038/s41598-025-09287-2. |
Journal Article
2025
|
Validation of the HR recovery method and description of the HRR30 parameter used in Kubios HRV training analytics. |
| Kubios HRV Scientific User’s Guide. Kubios Oy. | User’s Guide 2024 |
Documentation of Kubios HRV Scientific software features and functionalities. |
| Eronen T, Lipponen JA, Hyrylä V, Kupari S, Mursu J, Venojärvi M, Tikkanen HO, and Tarvainen MP. Heart rate variability based ventilatory threshold estimation – Validation of a commercially available algorithm. MedRxiv, Aug 2024, doi: https://doi.org/10.1101/2024.08.14.24311967. | MedRxiv 2024 |
Validation of the ventilatory threshold estimation algorithm used in Kubios HRV software products. |
| Lipponen JA and Tarvainen MP. Accuracy of Kubios HRV software respiratory rate estimation algorithms. Computing in Cardiology, 49(134), 2022. | Conference article 2022 |
Validation of the respiratory rate estimation algorithms used in Kubios HRV software products. |
| Lipponen JA and Tarvainen MP. A robust algorithm for heart rate variability time series artefact correction using novel beat classification. J Med Eng & Technol, 43(3):173-181, 2019. | Journal article 2019 |
Validation of the automatic beat correction algorithm used in Kubios HRV software products. |
| Tarvainen MP, Laitinen TP, Lipponen JA, Cornforth DJ, and Jelinek HF. Cardiac autonomic dysfunction in type 2 diabetes – effect of hyperglycemia and disease duration. Front Endocrinol, 5(Article 130):1-9, 2014. | Journal article 2014 |
Validation of Kubios HRV analysis methods in detecting cardiac autonomic dysfunction related to type 2 diabetes. |
| Tarvainen MP, Niskanen J-P, Lipponen JA, Ranta-aho PO, and Karjalainen PA. Kubios HRV – Heart rate variability analysis software. Comp Meth Programs Biomed, 113(1):210-220, 2014. | Journal article 2014 |
Latest scientific reference for Kubios HRV software (version 2.1). |
| Tarvainen MP, Georgiadis SD, Laitio T, Lipponen JA, Karjalainen PA, Kaskinoro K, and Scheinin H. Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia. Annals Biomed Eng, 40(8):1802-1813, 2012. | Journal article 2012 |
Validation of the Kalman smoother based time-varying spectrum estimation method (used in Kubios HRV Scientific software) in anesthesia monitoring. |
| Tarvainen MP, Georgiadis SD, Ranta-aho PO, and Karjalainen PA. Time-varying analysis of heart rate variability signals with Kalman smoother algorithm. Physiol Meas, 27(3):225-239, 2006. | Journal article 2006 |
Description of the Kalman smoother based time-varying spectrum estimation method (available in Kubios HRV Scientific). |
| Niskanen J-P, Tarvainen MP, Ranta-aho PO, and Karjalainen PA. Software for advanced HRV analysis. Comp Meth Programs Biomed, 76(1):73-81, 2004. | Journal article 2004 |
Original scientific reference for Kubios HRV software (version 1.1). |
| Tarvainen MP, Ranta-aho PO, and Karjalainen PA. An advanced detrending method with application to HRV analysis. IEEE Trans Biomed Eng, 49(2):172-175, 2002. | Journal article 2002 |
Scientific reference for the smoothness priors detrending method (used in Kubios HRV software products). |